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Heartburn

Eating spicy foods, such as pizza, may cause a person to feel heartburn. Although the name may imply the heart, heartburn has nothing to do with the heart itself. Heartburn is pain felt in the chest by a burning sensation in the esophagus.

Heartburn
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Health News

Register now to attend the next virtual meeting of the Dietary Guidelines Advisory Committee

Registration is now open for the next meeting of the 2025 Dietary Guidelines Advisory Committee. Scheduled to be held on Wednesday, May 29, from 1:00 to 5:30 PM ET, and Thursday, May 30, from 8:30 AM to 4:00 PM ET, the meeting will featu. See on Source

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10/04/2024

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ICYMI: Planning for Individual and Community Health Webinar Recording Now Available

On March 19, 2024, The Office of Disease Prevention and Health Promotion (ODPHP) hosted the Healthy People 2030 webinar Planning for Individual and Community Health. A recording of that webinar is now available.During this one-hour event. See on Source

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09/04/2024

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Portland, Oregon: Creating an Accessible Built Environment That Helps Residents Stay Active as They Age

This blog post is part of a spotlight series featuring examples of programs and community design changes that get older adults moving. The posts were first published as part of the Physical Activity Guidelines for Americans Midcourse Rep. See on Source

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03/04/2024

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New Article Details the Process Used to Develop the Dietary Guidelines for Americans

When it comes to healthy eating and nutrition, the Dietary Guidelines for Americans (Dietary Guidelines) is one of the best tools we have to help individuals in the United States get and stay healthy. As the nation's leading source of sc. See on Source

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03/04/2024

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Feeding Our Children Nutritious Foods Should Be the Easiest of Decisions

Health and Well-Being Matter is the monthly blog of the Director of the Office of Disease Prevention and Health Promotion. We are failing our children and future generations. In the United States in 2020, nearly 1 in 5 children and adole. See on Source

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28/03/2024

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April National Health Observances: Minority Health, Alcohol Awareness, and Public Health Week

Each month, we feature select National Health Observances (NHOs) that support our mission to improve health across the United States. In April, we’re raising awareness about minority health, alcohol use and misuse, and celebrating public. See on Source

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26/03/2024

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What 2 Healthy People 2030 Objectives Tell Us About the Nation’s Nutrition

When it comes to healthy diets, the science says to eat more vegetables and consume less sugar. And that’s what the Dietary Guidelines for Americans has told us for years. Nutrition is key to health and well-being, but as Healthy People . See on Source

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22/03/2024

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Florida Department of Health in Hillsborough County and ODPHP Share Tips to Get Older Adults Moving

In July 2023, ODPHP joined forces with the Association of State and Territorial Health Officials (ASTHO) and the National Association of County and City Health Officials (NACCHO) to host a webinar called Increasing Physical Activity Amon. See on Source

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21/03/2024

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Tools to Help Consumers Eat Healthy on a Budget

Nutrition is a thread that runs through all the work we do at ODPHP — because we know that maintaining a healthy and balanced diet is a critical way to prevent disease and promote good health. As the 2020–2025 Dietary Guidelines for Amer. See on Source

Health.gov

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06/03/2024

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University of California San Francisco Cardiac Rehab: Providing Comprehensive Support to Help People with Heart Disease Improve Their Health

This blog post is part of a spotlight series featuring examples of programs and community design changes that get older adults moving. The posts were first published as part of the Physical Activity Guidelines for Americans Midcourse Rep. See on Source

Health.gov

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05/03/2024

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UN News - Health

Global perspective, human stories

Hepatitis killing thousands daily, WHO warns in new report

The number of lives lost due to viral hepatitis infections is increasing and already accounts for 3,500 deaths daily, according to a report by the World Health Organization (WHO) released on Tuesday.. See on Source

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09/04/2024

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Mother makes 200km emergency trip across rural Madagascar to save baby

A young mother in Madagascar has been describing how she was forced to make a 200km emergency journey on challenging rural roads to a specialist regional hospital after she experienced difficulties giving birth at home.. See on Source

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06/04/2024

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Gaza: ‘Systematic dismantling of healthcare must end’ says WHO

With the largest hospital in Gaza largely destroyed and out of action, access to healthcare has now become “totally inadequate” following six months of brutal fighting between Israeli forces and Palestinian militants, said the World Health Organization (W. See on Source

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06/04/2024

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World News in Brief: Security Council condemns DR Congo attacks, cholera testing breakthrough, ‘my health, my right’ campaign

The UN Security Council on Friday strongly condemned the latest rise in attacks by the M23 rebel group in the Democratic Republic of the Congo’s restive east, which has undermined security and exacerbated an already dire humanitarian situation.. See on Source

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05/04/2024

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Sudan: Aid lifeline reaches Darfur region in bid to avert ‘hunger catastrophe’

Two aid convoys carrying lifesaving supplies have reached Sudan’s Darfurs for the first time in months, the UN World Food Programme (WFP) said on Friday, as humanitarians try to avert a “hunger catastrophe”, after nearly a year of heavy fighting.. See on Source

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05/04/2024

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WHO study shows $39 return for each dollar invested in fight against TB

The UN World Health Organization (WHO) on Monday called for a funding boost in tuberculosis (TB) screening and prevention programmes to protect vulnerable populations and achieve key health goals.. See on Source

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18/03/2024

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Explainer: What is famine?

Amid growing global concerns over alarming hunger spikes in conflict-affected communities and talk of intensifying levels of food insecurity possibly leading to famine, we looked into how – and when – a famine is classified.. See on Source

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18/03/2024

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‘Historic milestone’ as child mortality hits record low of 4.9 million in 2022

The fight against child mortality has reached an historic milestone the UN announced on Wednesday with latest estimates revealing the number of children dying prematurely before their fifth birthday fell to 4.9 million in 2022.. See on Source

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12/03/2024

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WHO: Investments and myth-busting to improve hearing

Over 400 million people globally need hearing aids, a study by the World Health Organization (WHO) reveals, but only 20 per cent get them due to lack of financial and human resources, as well as stigma. . See on Source

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02/03/2024

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World News in Brief: Another month of extreme heat, Sudan exodus continues into Chad, Zero Discrimination Day

February saw more extreme heat and unusually high temperatures in both hemispheres, the UN weather agency (WMO) said on Friday.. See on Source

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01/03/2024

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At least one in eight people now obese

At least one in eight people on Earth are living with obesity, the World Health Organization (WHO) said on Friday, citing a newly released global medical study.. See on Source

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29/02/2024

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Senior officials call for action and solutions at UN Environment Assembly

Leaders attending a major UN environmental conference in Nairobi must drive forward solutions to combat climate change, biodiversity loss and pollution, Secretary-General António Guterres said on Thursday. . See on Source

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29/02/2024

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No medicine, no hope: Doctors describe life under Israeli attack in Gaza

No communications, no medicine and little hope. That’s what operating a hospital in a war zone has become in Gaza, according to a team of doctors trapped for weeks inside the besieged Al Amal Hospital in Khan Younis.. See on Source

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28/02/2024

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World News in Brief: Noncommunicable diseases in emergencies, aid plan for Haiti, peace efforts in CAR

People caught up in humanitarian emergencies are at increased risk of cardiovascular disease, cancer, diabetes and other noncommunicable diseases (NCDs), UN agencies and partners warned on Tuesday. . See on Source

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27/02/2024

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General Assembly President calls for solidarity with Ukraine as ‘needless war’ reaches two-year mark

UN General Assembly President Dennis Francis urged countries to stand with the people of Ukraine “in their quest for justice and peace” during a meeting on Friday to mark two years of Russia’s full-scale invasion of the country. . See on Source

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23/02/2024

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First Person: Supporting mental health in Madagascar, one consultation at a time

Ongoing humanitarian crises in southern Madagascar have worsened the situation for people with mental health disorders, but the UN’s World Health Organization (WHO) has been supporting patients by providing more psychiatric consultations.. See on Source

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18/02/2024

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Stories from the UN Archive: Boris Karloff, leprosy and Nigeria

As the world celebrates World Radio Day, marked on 13 February, we dug into the UN archives for a vintage podcast classic from 1959, when famed Frankenstein actor Boris Karloff narrated an episode describing a visit to a leprosy clinic in Tiranka, Nigeria. See on Source

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13/02/2024

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World News in Brief: Unprecedented cholera spike in Africa, Julian Assange extradition update, locusts compound Sudan crisis

Cholera cases are surging globally, and there’s been an unprecedented spike in Africa, the World Health Organization (WHO) said on Tuesday. . See on Source

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06/02/2024

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Cancer rates set to rise 77 per cent by 2050

Global cancer cases are expected to rise around 77 per cent by the middle of the century, UN health authorities said on Thursday, highlighting the growing burden of the disease. . See on Source

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01/02/2024

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Featured News from HSPH

Climate change contributing to rise in immune health problems

Diseases related to problems in immune health—from nasal allergies to food allergies to rheumatoid arthritis to colorectal cancer—have spiked in recent years, and climate change appears to be playing a role, according to Harvard Chan School’s Kari Nadeau.... See on Source

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11/04/2024

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Startup for transgender health care wins venture award

The startup Trans Health HQ—founded by Ivan Hsiao, a student at Harvard Chan School—has been named runner-up in the Social Enterprise Track of the 2024 Harvard Business School New Venture Competition.... See on Source

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11/04/2024

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Racial, ethnic disparities persist in U.S. tuberculosis cases

Racial and ethnic disparities in tuberculosis incidence persist among the U.S.-born population, according to a new study led by Harvard Chan School.... See on Source

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08/04/2024

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Federal policy kept millions on Medicaid rolls during pandemic—but many didn’t realize they still had coverage

Far more people were enrolled in Medicaid during the pandemic than who reported in surveys having coverage—a discrepancy suggesting that many people were unaware that their coverage had continued under federal policies, according to a new Harvard Chan Sch... See on Source

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08/04/2024

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How studying the ‘exposome’ can reveal harmful environmental exposures

In the not-too-distant future, doctors may be able to determine what sort of damaging exposures their patients have faced—everything from toxic chemicals to unhealthy foods—all from a blood test. This largely invisible collection of exposures is known as ... See on Source

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08/04/2024

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Carnivore diet a ‘terrible idea’

Some social media influencers are promoting a so-called “carnivore diet” made up almost entirely of animal products such as beef, butter, and eggs.... See on Source

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05/04/2024

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Viewpoint: Questioning Medicare Advantage ‘affinity plans’

A March 20 JAMA Viewpoint article discusses a growing category of Medicare Advantage plans—what the authors call “affinity plans”—and argues that these plans come with dangers for patients.... See on Source

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04/04/2024

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Optimism may help women maintain physical functioning as they age

An optimistic attitude may help women slow age-related physical decline.... See on Source

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03/04/2024

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Documentary explores ‘invisible’ work of public health

A new PBS documentary about the importance of public health features Harvard Chan School’s Mary Bassett.... See on Source

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03/04/2024

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Rochelle Walensky reflects on experiences as former CDC director

The Centers for Disease Control and Prevention (CDC) faces challenges such as communicating public health policies to the public, modernizing data collection, and having limited governmental authority to collect data, according to Rochelle Walensky, CDC d... See on Source

hsph.harvard.edu

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03/04/2024

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JPET current issue

Journal of Pharmacology and Experimental Therapeutics

The Effects of Chronic Naltrexone on Reinstatement of Opioid-Induced Drug-Seeking Behavior and Antinociception [Behavioral Pharmacology]

Opioid addiction is a chronic relapsing disorder in which drug-seeking behavior during abstinence can be provoked by exposure to a µ-opioid receptor (MOR) agonist or opioid-associated cues. Opioid self-administration behavior in laboratory subjects... See on Source

jpet.aspetjournals.org

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12/04/2024

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The Neutrophil Dynamic Mass Redistribution Assay as a Medium throughput Primary Cell Screening Assay [Drug Discovery and Translational Medicine]

In a typical G protein coupled receptor drug discovery campaign, an in vitro primary functional screening assay is often established in a recombinant system overexpressing the target of interest, which offers advantages with respect to overall throughput... See on Source

jpet.aspetjournals.org

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12/04/2024

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Obituary: Travis Thompson--Editorial [Editorial]

... See on Source

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12/04/2024

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Endothelial Extracellular Vesicles Enriched in microRNA-34a Predict New-Onset Diabetes in Coronavirus Disease 2019 (COVID-19) Patients: Novel Insights for Long COVID Metabolic Sequelae [Cardiovascular]

Emerging evidence indicates that the relationship between coronavirus disease 2019 (COVID-19) and diabetes is 2-fold: 1) it is known that the presence of diabetes and other metabolic alterations poses a considerably high risk to develop a severe COVID-19... See on Source

jpet.aspetjournals.org

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12/04/2024

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N-Acetylcysteine Alters Disease Progression and Increases Janus Kinase Mutation Frequency in a Mouse Model of Precursor B-Cell Acute Lymphoblastic Leukemia [Cellular and Molecular]

B-cell acute lymphoblastic leukemia (B-ALL) is the most prevalent type of cancer in young children and is associated with high levels of reactive oxygen species (ROS). The antioxidant N-acetylcysteine (NAC) was tested for its ability to alter disease pro... See on Source

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12/04/2024

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Lucanthone, a Potential PPT1 Inhibitor, Perturbs Stemness, Reduces Tumor Microtube Formation, and Slows the Growth of Temozolomide-Resistant Gliomas In Vivo [Chemotherapy, Antibiotics, and Gene Therapy]

Glioblastoma (GBM) is the most frequently diagnosed primary central nervous system tumor in adults. Despite the standard of care therapy, which includes surgical resection, temozolomide chemotherapy, radiation and the newly added tumor-treating fields, m... See on Source

jpet.aspetjournals.org

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12/04/2024

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Development of Cilofexor, an Intestinally-Biased Farnesoid X Receptor Agonist, for the Treatment of Fatty Liver Disease [Drug Discovery and Translational Medicine]

The farnesoid X receptor (FXR) is a nuclear receptor that controls bile acid, lipid, and cholesterol metabolism. FXR-targeted drugs have shown promise in late-stage clinical trials for non-alcoholic steatohepatitis. Herein, we used clinical results from ... See on Source

jpet.aspetjournals.org

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12/04/2024

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Suppression of Mast Cell Activation by GPR35: GPR35 Is a Primary Target of Disodium Cromoglycate [Inflammation, Immunopharmacology, and Asthma]

Mast cell stabilizers, including disodium cromoglycate (DSCG), were found to have potential as the agonists of an orphan G protein–coupled receptor, GPR35, although it remains to be determined whether GPR35 is expressed in mast cells and involved i... See on Source

jpet.aspetjournals.org

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12/04/2024

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Humanization of SLCO2B1 in Rats Increases rCYP3A1 Protein Expression but Not the Metabolism of Erlotinib to OSI-420 [Metabolism, Transport, and Pharmacogenetics]

The organic anion transporting polypeptide (OATP)2B1 [(gene: solute carrier organic anion transporter family member 2B1 (SLCO2B1)] is an uptake transporter that facilitates cellular accumulation of its substrates. Comparison of SLCO2B1+/+ knockin and rSl... See on Source

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12/04/2024

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Pharmacokinetics of Panobinostat: Interspecies Difference in Metabolic Stability [Metabolism, Transport, and Pharmacogenetics]

The deregulation of histone deacetylase (HDAC) expression is often seen in many cancers, and HDAC inhibitors have shown potency against a variety of cancer types. Panobinostat is a potent pan-HDAC inhibitor that has been tested in multiple studies for th... See on Source

jpet.aspetjournals.org

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12/04/2024

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NCP, a Dual Kappa and mu Opioid Receptor Agonist, Is a Potent Analgesic Against Inflammatory Pain without Reinforcing or Aversive Properties [Neuropharmacology]

While agonists of μ (MOR) and (KOR) opioid receptors have analgesic effects, they produce euphoria and dysphoria, respectively. Other side effects include respiratory depression and addiction for MOR agonists and sedation for KOR agonists. We reporte... See on Source

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12/04/2024

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Selective KCNQ2/3 Potassium Channel Opener ICA-069673 Inhibits Excitability in Mouse Vagal Sensory Neurons [Neuropharmacology]

Heightened excitability of vagal sensory neurons in inflammatory visceral diseases contributes to unproductive and difficult-to-treat neuronally based symptoms such as visceral pain and dysfunction. Identification of targets and modulators capable of reg... See on Source

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12/04/2024

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