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Heartburn

Eating spicy foods, such as pizza, may cause a person to feel heartburn. Although the name may imply the heart, heartburn has nothing to do with the heart itself. Heartburn is pain felt in the chest by a burning sensation in the esophagus.

Heartburn
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Health News

Register Today for an NYSS Coaching Webinar!

Youth sports are a great way for kids and teens to get the recommended amount of physical activity each day and give them the confidence they need to succeed in life. The Office of Disease Prevention and Health Promotion (ODPHP) is pleas. See on Source

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22/05/2024

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ODPHP’s Dr. Katrina Piercy Appears on Public Health Review Morning Edition to Celebrate Older Americans Month

Each May, Older Americans Month — led by the Administration for Community Living — celebrates the contributions of older adults and reaffirms commitments to serving the older adults in our communities. This year’s theme, “Powered by Conn. See on Source

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22/05/2024

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Assistant Secretary for Health to Join Members of President's Council for Panel on Physical Activity and Mental Health

On Tuesday, May 28 at 2 pm, the Assistant Secretary for Health for HHS and members of the President’s Council on Sports, Fitness & Nutrition (PCSFN) will meet on a discussion panel at the National Press Club in Washington, DC, to add. See on Source

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20/05/2024

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Use Move Your Way® Materials to Get Older Adults Moving in Your Community!

May is Older Americans Month and National Physical Fitness & Sports Month — and to celebrate, ODPHP is inviting you to use Move Your Way materials for older adults in your work.Move Your Way is the promotional campaign for the Physic. See on Source

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17/05/2024

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ODPHP Wins the Grand ClearMark Award for MyHealthfinder Anxiety Topics Pages

The Center for Plain Language has honored ODPHP and CommunicateHealth with its 2024 Grand ClearMark Award for the new MyHealthfinder Anxiety Topics pages. Judges said that it “conveys a clear sense that the authors carefully considered t. See on Source

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13/05/2024

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Announcing Nomination Period for 2024 President’s Council on Sports, Fitness & Nutrition Awards

The President’s Council on Sports, Fitness & Nutrition (PCSFN) announces the nomination period for the 2024 Council Awards. The 2024 Council Awards recognize individuals or organizations that have contributed in various ways to the a. See on Source

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06/05/2024

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Get Active to Support Your Mental Health During National Physical Fitness and Sports Month

In May we observe National Physical Fitness and Sports Month. Since 1983, each President has publicly recognized and promoted the importance of physical activity to good overall health. This year, President Biden issued a Proclamation co. See on Source

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01/05/2024

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Registration Is Now Open for the Next Healthy People 2030 Webinar, Air Quality Matters: Improving Health and Lung Function with Healthy People 2030 Objectives

The Office of Disease Prevention and Health Promotion (ODPHP) is pleased to announce its next Healthy People 2030 webinar: Air Quality Matters: Improving Health and Lung Function with Healthy People 2030 Objectives. This webinar will ta. See on Source

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29/04/2024

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Detroit Parks & Recreation: Focusing on Fun to Keep Older Adults Active and Connected

This blog post is part of a spotlight series featuring examples of programs and community design changes that get older adults moving. The posts were first published as part of the Physical Activity Guidelines for Americans Midcourse Rep. See on Source

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23/04/2024

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May National Health Observances: Physical Fitness, Mental Health, Older Adults, and Women’s Health

Each month, we feature select National Health Observances (NHOs) that support our mission to improve health across the United States. In May, we’re raising awareness about physical fitness, mental health, older adults’ health and well-be. See on Source

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22/04/2024

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UN News - Health

Global perspective, human stories

Stories from the UN Archive: Magic suitcases for 1960s midwives

Can a magic suitcase save lives?. See on Source

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22/05/2024

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‘Critical gaps’ in understanding climate change fuel tropical disease spread

A comprehensive review by the UN health agency has revealed critical gaps in understanding the full impact of climate change on malaria, dengue, trachoma and other tropical diseases.. See on Source

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22/05/2024

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WHO reports major increase in sexually transmitted infections

Sexually transmitted infections (STIs) such as syphilis are on the rise in most regions of the world, UN health agency WHO said in a new report on Tuesday. . See on Source

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21/05/2024

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Syria: WHO Regional Director calls for greater investment in health sector

Failure to invest in the health of the Syrian people will only deepen instability in the war-ravaged country and pose threats to regional and global security, a senior official with the World Health Organization (WHO) has said.. See on Source

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19/05/2024

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World News in Brief: Vaccine ‘patches’ trial shows promise, lowering catheter infection risk, Guantanamo detainee facing revictimisation

Few enjoy having injections and if you have children, you probably like them even less when it’s time for their mandated vaccine shots.. See on Source

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09/05/2024

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No sign yet of H5N1 bird flu spreading between humans, says WHO chief

The H5N1 avian influenza virus has so far shown no signs of adapting to allow human-to-human transmission, the UN health agency said on Wednesday, urging continued surveillance.. See on Source

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08/05/2024

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Patients in Rafah ‘afraid to seek services’, WHO reports

The World Health Organization (WHO) has taken “crucial steps” in preparation for a large-scale Israeli military operation in Rafah, Dr. Ahmed Dahir, team lead of its office in Gaza, told UN News on Tuesday.. See on Source

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07/05/2024

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Peace or war, midwives keep delivering

Millions of lives each year rely on the expertise and care of midwives and yet a global shortage is squeezing the profession like never before, the UN sexual and reproductive health agency UNPFA said on Sunday, marking the International Day of the Mi. See on Source

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05/05/2024

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First Person: Women in Madagascar too ashamed to seek help giving birth

Some of the poorest women in an underdeveloped region south of Madagascar are “too ashamed” to seek the maternal health services they need, according to a midwife working in a health centre supported by United Nations agencies, but that may be about to ch. See on Source

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05/05/2024

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Europe: Report highlights direct link between pandemic and childhood obesity

The COVID-19 pandemic has led to increased obesity in school-aged children in Europe, the World Health Organization (WHO) office for the region said in a new report issued on Wednesday, sounding the alarm for action. . See on Source

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01/05/2024

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‘Just in case’ antibiotics widely overused during COVID-19, says UN health agency

Antibiotics saw “extensive overuse” globally among hospitalised COVID-19 patients during the pandemic without improving clinical outcomes, while also potentially increasing the already serious and growing threat of antimicrobial resistance from "superbugs. See on Source

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26/04/2024

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Gender therapy review reveals devastating impacts on teens

A top Human Rights Council-appointed expert has welcomed the decision by all health authorities in the United Kingdom to halt the routine use of puberty-blockers offered to children as part of gender transition services, amid a sharp increase more widely . See on Source

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25/04/2024

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Teen alcohol and nicotine use in Europe is up, WHO urges preventive measures

Smoking and drinking is on the rise among teenagers in Europe, Central Asia and Canada, and girls now match or even exceed boys when it comes to substance use, the World Health Organization (WHO) said in a new report on Thursday.. See on Source

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25/04/2024

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New global campaign boosts lifesaving vaccines

Two UN agencies alongside the Bill and Melinda Gates Foundation and the global vaccine alliance Gavi launched on Wednesday a campaign to scale up programmes to save lives, marking the start of World Immunisation Week, celebrated annually during the last w. See on Source

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24/04/2024

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Latest hunger data spotlights extent of famine risk in Gaza, Sudan and beyond

Dangerous levels of acute hunger affected a staggering 281.6 million people last year – the fifth year in a row that food insecurity has worsened – heightening growing fears of famine and “widespread death” from Gaza to Sudan and beyond, UN agencies warne. See on Source

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24/04/2024

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Heatwave deaths increased across almost all Europe in 2023, says UN weather agency

Climate change shocks caused record levels of disruption and misery for millions in Europe in 2023 with widespread flooding and severe heatwaves – a new normal which countries must adapt to as a priority, the UN weather agency said on Monday. . See on Source

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22/04/2024

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Pandemic experts express concern over avian influenza spread to humans

The ongoing global spread of “bird flu” infections to mammals including humans is a significant public health concern, senior UN medics said on Thursday as they announced new measures to tackle airborne diseases.. See on Source

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18/04/2024

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Violations of women’s reproductive health rights trigger rise in preventable deaths

African women are 130 times more likely to die due to pregnancy or childbirth complications than women in Europe and Northern America, the UN sexual and reproductive health agency (UNFPA) said in a new report published on Wednesday.. See on Source

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17/04/2024

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Nigeria first country to introduce ‘revolutionary’ meningitis vaccine

Nigeria has become the first country to roll out a “revolutionary” five-in-one vaccine against meningitis, the World Health Organization (WHO) said in a statement on Friday.  . See on Source

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12/04/2024

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Featured News from HSPH

Identifying risk factors for suicidal ideation in Indian adolescent girls

Adolescent girls in India have a higher risk of suicidal ideation if they experience psychological distress or intergenerational violence, according to a study.... See on Source

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22/05/2024

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Envisioning tobacco’s ‘endgame’

Laws prohibiting the sale of tobacco products to people born after a certain year—reflecting the concept of a Tobacco-Free Generation (TFG)—are likely to gain steam in the months and years to come, according to Harvard Chan School’s Howard Koh.... See on Source

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16/05/2024

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Ultra-processed foods—some more than others—linked to early death

High intake of ultra-processed foods—particularly processed meats, sugary breakfast foods, and sugar- or artificially sweetened beverages—may increase risk of early death, according to a Harvard Chan School study.... See on Source

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15/05/2024

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Olive oil may reduce risk of death from dementia

People who incorporate olive oil into their everyday diet may decrease their risk of dementia-related death, according to a new Harvard Chan School study.... See on Source

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14/05/2024

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‘No safe amount of exposure’ to gas stove pollution

People living in U.S. households with gas stoves may regularly breathe in unsafe levels of nitrogen dioxide, according to a new study co-authored by Harvard Chan School’s Kari Nadeau.... See on Source

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14/05/2024

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Widespread aspirin use after chest pain could significantly reduce heart attack deaths

If most people in the U.S. took aspirin within hours of experiencing severe chest pain, it could delay more than 13,000 heart attack deaths every year, according to a new Harvard Chan School study.... See on Source

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14/05/2024

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Dyann Wirth receives lifetime achievement award for malaria research

Harvard Chan School's Dyann Wirth has received a top award from the Multilateral Initiative on Malaria Society for playing a pivotal role in the global fight against malaria.... See on Source

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14/05/2024

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Cholesterol-transporting molecule may increase Alzheimer’s risk

Having higher levels of a certain lipoprotein—a molecule that helps carry fat around the body—may increase people’s risk of developing Alzheimer’s disease.... See on Source

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13/05/2024

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Fiber and fermented foods may aid microbiome, overall health

It’s well-known that eating a diet rich in fiber and fermented foods fosters healthy digestion, but research suggest that these foods may offer additional health benefits.... See on Source

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10/05/2024

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Age, sex may be important to consider in assessing tuberculosis risk

How an individual’s immune system responds to the bacteria that causes tuberculosis—and therefore whether they develop the disease—may differ across age and sex, according to a new study co-led by Harvard Chan School’s Sarah Fortune.... See on Source

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10/05/2024

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JPET current issue

Journal of Pharmacology and Experimental Therapeutics

Professional Pharmacology and Pharmacy Organization Responses to the Dobbs v. Jackson Supreme Court Ruling [ASPET 2024 Annual Meeting Abstract - Other Topics]

Abstract ID 129036 Poster Board 001 Objective/Hypothesis: The US Supreme Court’s decision in Dobbs v. Jackson Women’s Health Organization has sparked significant changes in reproductive healthcare laws, allowing individual states to regulate ... See on Source

jpet.aspetjournals.org

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23/05/2024

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Neurostimulation of the renal nerves as a novel therapeutic option for obstructive sleep apnea treatment [ASPET 2024 Annual Meeting Abstract - Translational Systems and Clinical Pharmacology]

Abstract ID 79893 Poster Board 002 Obstructive sleep apnea (OSA) is a prevalent sleep-related breathing disorder marked by recurrent upper airway collapse during sleep, resulting in sleep disruption, reduced oxygen saturation, and an increased risk of mo... See on Source

jpet.aspetjournals.org

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23/05/2024

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No Evidence for Beneficial Empagliflozin Effects in the Kidney of Female Rats in a Streptozotocin-induced Model of Type 1 Diabetes [ASPET 2024 Annual Meeting Abstract - Translational Systems and Clinical Pharmacology]

Abstract ID 93344 Poster Board 003 Introduction A recent systematic review on the effects of SGLT2 inhibitors such as empagliflozin in rodent models of diabetic nephropathy found that this drug class had marked beneficial effects across all members of th... See on Source

jpet.aspetjournals.org

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23/05/2024

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Biased Allosteric Modulation of {beta}2-adrenergic Receptor Signaling and Bronchodilation by different {beta}-agonists [ASPET 2024 Annual Meeting Abstract - Translational Systems and Clinical Pharmacology]

Abstract ID 94144 Poster Board 004 Objective & Hypothesis: β-agonist serves as the frontline treatment of obstructive airway diseases like asthma and COPD to induce very essential functions - airway smooth muscle (ASM) relaxation and bronchodila... See on Source

jpet.aspetjournals.org

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23/05/2024

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Effects of Long-term Endogenous Acetylcholine Deficiency in Lung Inflammation in a Model of Asthma-copd Overlap in Mice [ASPET 2024 Annual Meeting Abstract - Translational Systems and Clinical Pharmacology]

Abstract ID 128092 Poster Board 005 Cholinergic anti-inflammatory system, especially by activation of nicotinic receptors, has been shown to modulate lung inflammation in several models of lung diseases. ACO is a syndrome that involves asthma and COPD fe... See on Source

jpet.aspetjournals.org

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23/05/2024

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Poly (ADP) Ribose Polymerase (PARP)-1 as a novel therapeutic target for alleviating the manifestations of Atopic Dermatitis [ASPET 2024 Annual Meeting Abstract - Translational Systems and Clinical Pharmacology]

Abstract ID 102930 Poster Board 006 Background: Atopic dermatitis (AD) is a multifaceted and multifactorial chronic inflammatory skin disorder. Patients with AD have few treatment choices. Therefore, understanding the main molecular pathways involved in ... See on Source

jpet.aspetjournals.org

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23/05/2024

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Plasma Metabolome Differences in Kidney Transplant Recipients with Biopsy Proven Acute Rejection versus Stable Grafts During the First Year Post-Transplant [ASPET 2024 Annual Meeting Abstract - Translational Systems and Clinical Pharmacology]

Abstract ID 128738 Poster Board 007 Objective: To determine if there is a difference in plasma metabolome from routine clinic sampling in kidney transplant patients with biopsy-proven acute rejection (T-cell or antibody mediated) and stable grafts during... See on Source

jpet.aspetjournals.org

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23/05/2024

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Intranasal or Intraperitoneal Insulin and Oral Metformin, Given Separately or in Co-administration, Prevent Aggravation of Gastric Erosions in Rat with Type 1 Diabetes [ASPET 2024 Annual Meeting Abstract - Translational Systems and Clinical Pharmacology]

Abstract ID 129289 Poster Board 008 Diabetes remains a pressing issue, and its prevalence is steadily increasing. With the increase in the prevalence of diabetes, the number of severe complications of this disease is also growing. Among them, alongside n... See on Source

jpet.aspetjournals.org

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23/05/2024

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Extracellular Matrix Metalloproteinases-9 Profile: Shedding Light on the Polycystic Ovary Syndrome in Jordanian Females [ASPET 2024 Annual Meeting Abstract - Translational Systems and Clinical Pharmacology]

Abstract ID 130398 Poster Board 009 Introduction: Polycystic ovary syndrome (PCOS) is a chronic endocrine and reproductive disorder that globally impacts females of reproductive age. This condition is marked by such as hyperandrogenism, polycystic ovarie... See on Source

jpet.aspetjournals.org

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23/05/2024

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Protein-protein interactions in endothelial cell von Willebrand factor secretion and exocytosis [ASPET 2024 Annual Meeting Abstract - Translational Systems and Clinical Pharmacology]

Abstract ID 131354 Poster Board 010 Exocytosis is a fundamental process for all eukaryotes and is linked to important human diseases. My previous results and that of Voyno-Yesnestaka (Andreeva et al., JBC, 2005) demonstrate that Galpha12 G protein intera... See on Source

jpet.aspetjournals.org

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23/05/2024

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Finasteride induces Cytoarchitectural Alterations in Hippocampus of Adult Male Wistar Rat: A Contributor to Neuropsychiatric Effects of Post-Finasteride Syndrome [ASPET 2024 Annual Meeting Abstract - Toxicology]

Abstract ID 79464 Poster Board 011 The hippocampus is a part of the limbic system of the brain that contribute to learning, memory and emotions. It receives signals from regulatory neurotransmitter systems, such as serotonin, norepinephrine, dopamine, an... See on Source

jpet.aspetjournals.org

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23/05/2024

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Screening of plant extracts in achieving novel strategy in promoting efficacy and combat Cisplatin-induced neurotoxicity [ASPET 2024 Annual Meeting Abstract - Toxicology]

Abstract ID 93616 Poster Board 012 Chemotherapy is an elementary cancer treatment employed to target rapidly dividing cancer cells. Among various therapeutic approaches such as immunotherapy, chemotherapy, targeted therapy, radiation, and surgery, chemot... See on Source

jpet.aspetjournals.org

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23/05/2024

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Lung Injury in Mice from Acute Cutaneous Exposure to Vesicating Agent Nitrogen Mustard [ASPET 2024 Annual Meeting Abstract - Toxicology]

Abstract ID 97752 Poster Board 013 1. Department of Pharmacology and Toxicology, College of Osteopathic Medicine, Michigan State University, East Lansing, MI. 2. Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Mic... See on Source

jpet.aspetjournals.org

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23/05/2024

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Repaving the Regulatory Road From Animal Models to New Approach Methods [ASPET 2024 Annual Meeting Abstract - Toxicology]

Abstract ID 100172 Poster Board 014 Background: There is increasing interest in the development and adoption of alternative methods aimed at replacing, reducing, and refining (3Rs) the use of animals in preclinical biomedical, pharmacological, and regula... See on Source

jpet.aspetjournals.org

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23/05/2024

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Melatonin Renoprotection against Vancomycin Toxicity: Dual Activation of Melatonin Receptors and NRF2 Signaling [ASPET 2024 Annual Meeting Abstract - Toxicology]

Abstract ID 100225 Poster Board 015 Background and Purpose Vancomycin-associated acute kidney injury (VA-AKI) is a critical concern in hospitalized patients with sepsis. Frequent use of vancomycin, a broad-spectrum antibiotic, to empirically treat septic... See on Source

jpet.aspetjournals.org

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23/05/2024

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Does the BCL-2 Inhibitor Venetoclax Increase the Risk of Cancer? A Real-World Pharmacovigilance Study [ASPET 2024 Annual Meeting Abstract - Toxicology]

Abstract ID 100272 Poster Board 016 Venetoclax (VCX) is a novel BCL-2 inhibitor approved by the FDA for treating leukemia and Lymphoma. A recent study from our research laboratory has unexpectedly demonstrated that inhibition of BCL-2 in mice by VCX incr... See on Source

jpet.aspetjournals.org

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23/05/2024

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Identification of Potential Targets Mediating Polymyxin Toxicity in Human Alveolar Epithelial Cells [ASPET 2024 Annual Meeting Abstract - Toxicology]

Abstract ID 128217 Poster Board 017 Inhaled polymyxins are highly beneficial for treating lung infections caused by multidrug-resistant Gram-negative bacteria. However, the mechanisms underlying polymyxin-induced toxicity in human lung epithelial cells r... See on Source

jpet.aspetjournals.org

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23/05/2024

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Microcystin-LR activates MAPKs and alters the phosphoproteome in human HepaRG cells [ASPET 2024 Annual Meeting Abstract - Toxicology]

Abstract ID 129698 Poster Board 018 Hepatocellular carcinoma (HCC) accounts for about 90% of all liver cancer cases and has poor prognosis for survival in advanced stages. Microcystin-LR (MCLR) is a potent hepatotoxin that has been linked to the developm... See on Source

jpet.aspetjournals.org

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23/05/2024

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Micro-dosing Mindfulness and Wellness Messages into Pharmacology Classrooms Improves Pharmacy Students Resilience [ASPET 2024 Annual Meeting Abstract - Pharmacology Education]

Abstract ID 87216 Poster Board 019 Background: Research studies indicate that offering students wellness resources, such as mindfulness exercises, can improve student well-being. This study assessed the effect of a 10-week wellness intervention - in-clas... See on Source

jpet.aspetjournals.org

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23/05/2024

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Feedback from Third-Year Medical Students on Reconstructed Pre-clerkship Pharmacology Curriculum [ASPET 2024 Annual Meeting Abstract - Pharmacology Education]

Abstract ID 91466 Poster Board 020 Abstract Text Objective To describe the revision of a pre-clerkship pharmacology curriculum and evaluate the impact, over a three-year period, of the revision on third-year medical students’ opinions of preparedne... See on Source

jpet.aspetjournals.org

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23/05/2024

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Street Medicine (SM) as a strategy for applying core concepts in pharmacology in Medical Education [ASPET 2024 Annual Meeting Abstract - Pharmacology Education]

Abstract ID 92671 Poster Board 021 Background: Current literature indicates that medical students who participate in free community clinics enhance their integration of basic science knowledge. However, no studies investigate any direct connection betwee... See on Source

jpet.aspetjournals.org

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23/05/2024

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Faculty Perspective on Implementing a Question-Writing Activity in Physician Assistant Pharmacology Courses [ASPET 2024 Annual Meeting Abstract - Pharmacology Education]

Abstract ID 97522 Poster Board 022 Medical education literature shows that formative assessment greatly benefits learners, especially in the basic sciences. However, the faculty workload to prepare questions or the cost of commercially available question... See on Source

jpet.aspetjournals.org

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23/05/2024

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Evaluating Preclinical Medical School Integration of Diversity and Bias Awareness Education Related to Analgesia and Opioid Use Disorder [ASPET 2024 Annual Meeting Abstract - Pharmacology Education]

Abstract ID 97879 Poster Board 023 Background/Purpose: Despite efforts to enhance opioid and analgesic education, data from our institution suggests effective integration of diversity and healthcare disparity has been challenging. Racial bias and health ... See on Source

jpet.aspetjournals.org

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23/05/2024

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Blended learning in pharmacology: Elevating cognitive skills, engagement and academic outcomes [ASPET 2024 Annual Meeting Abstract - Pharmacology Education]

Abstract ID 99151 Poster Board 024 Pharmacology education is crucial for health professionals, but it faces challenges with traditional methods such as lecture-based learning (LBL), which often fail to fully address complex concepts. Newer approaches, su... See on Source

jpet.aspetjournals.org

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23/05/2024

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Unscrambling Drugs: a Word Scramble Game for an Undergraduate Pharmacy Course [ASPET 2024 Annual Meeting Abstract - Pharmacology Education]

Abstract ID 102424 Poster Board 025 Dissemination of course contents in different modalities has been popularised by their demonstrated success to engage learners. Specifically, knowledge retention is improved upon using various forms of technology-assis... See on Source

jpet.aspetjournals.org

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23/05/2024

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Gamifying Pharmacology Education: An Innovative VR Approach [ASPET 2024 Annual Meeting Abstract - Pharmacology Education]

Abstract ID 125903 Poster Board 026 Background: Although gamification has proven effective in improving student learning and engagement, there is limited information on the application of immersive virtual reality (VR) games in medical education, particu... See on Source

jpet.aspetjournals.org

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23/05/2024

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Using a Clinical Pharmacology Elective to vertically Integrate Basic Pharmacology Content Beyond the Pre-clerkship Phase [ASPET 2024 Annual Meeting Abstract - Pharmacology Education]

Abstract ID 129230 Poster Board 027 Purpose: A recent trend in the evolving landscape of medical education involves expanding the clerkship phase. There is concern, however, that a condensed pre-clerkship phase may compromise the acquisition of basic sci... See on Source

jpet.aspetjournals.org

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23/05/2024

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Novel LC-MS/MS Targeted Analysis Shows that Retinol to RBP4 and TTR to RBP4 Ratio Decreases in Individuals with Diabetic Kidney Disease [ASPET 2024 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)]

Abstract ID 90343 Poster Board 028 Retinol binding protein 4 (RBP4) is critical in transport of retinol (vitamin A). RBP4 is also an adipokine. Elevated circulating RBP4 has been proposed as a biomarker of chronic kidney disease (CKD) and diabetes. Howev... See on Source

jpet.aspetjournals.org

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23/05/2024

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Population Pharmacokinetic/Pharmacodynamic Modeling and Simulation of a Flat Quarterly Riliprubart Dosing Regimen for Patients With Cold Agglutinin Disease [ASPET 2024 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)]

Abstract ID 92096 Poster Board 029 Introduction: Riliprubart is a humanized immunoglobulin G4 monoclonal antibody that inhibits the active form of C1s, preventing activation of the classical complement pathway (CP), whilst leaving the lectin and the alte... See on Source

jpet.aspetjournals.org

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23/05/2024

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Emergence of Irreversibility in Simple Signaling Modules [ASPET 2024 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)]

Abstract ID 91135 Poster Board 030 Bistability in signaling modules, vital in systems biology and pharmacology, is crucial for understanding cellular decision-making and irreversibility in signaling processes. Governing various cellular functions, signal... See on Source

jpet.aspetjournals.org

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23/05/2024

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High Dose Acetaminophen has no Acute Impact on the Integrity of the Blood-Brain Barrier in Mice [ASPET 2024 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)]

Abstract ID 92047 Poster Board 031 Background: We have recently established the highly specific and sensitive, stable isotope-labeled permeability marker [13C] Sucrose for measuring the integrity of the blood-brain barrier (BBB), and used it to demonstra... See on Source

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23/05/2024

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Effect of Pro-inflammatory Cytokines on the mRNA Abundance of Major Intestinal Drug Transporters [ASPET 2024 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)]

Abstract ID 92080 Poster Board 032 In vivo studies suggest that inflammation or infections can markedly alter drug clearance, thereby affecting drug effectiveness and safety (Morgan E. T. et al., 2009). This alteration in drug clearance is caused by the ... See on Source

jpet.aspetjournals.org

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23/05/2024

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Fusobacterium nucleatum Metabolites Activate Aryl Hydrocarbon Receptor and Promote Colorectal Cancer Cell Proliferation [ASPET 2024 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)]

Abstract ID 90348 Poster Board 033 The gut microbiota has emerged as a key contributor to host health and disease. A vast cell number and large genome size grant bacteria the ability to produce a myriad of metabolites that can impact host physiology bene... See on Source

jpet.aspetjournals.org

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23/05/2024

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Clinical Validation of a Physiologically Based Pharmacokinetic Model-Predicted Intestinal Natural Product-Drug Interaction [ASPET 2024 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)]

Abstract ID 95893 Poster Board 034 Background: The widely used botanical dietary supplement goldenseal is an established clinical inhibitor of cytochrome P450 (CYP) 3A activity, as evidenced by a 40-50% increase in the area under the plasma concentration... See on Source

jpet.aspetjournals.org

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23/05/2024

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Non-Nutritive Sweeteners Inhibit Key Multidrug Efflux Transporters [ASPET 2024 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)]

Abstract ID 94413 Poster Board 035 Non-nutritive sweeteners (NNS) are popular sugar replacements used in a wide range of foods, beverages, and medications. Although NNS are recognized as safe by the Food and Drug Administration, the effects of NNS on spe... See on Source

jpet.aspetjournals.org

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23/05/2024

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Biochemical Characterization of Human Cytochrome P450 7B1 Missense Mutations to Understand Spastic Paraplegia Type 5 Disease [ASPET 2024 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)]

Abstract ID 94281 Poster Board 036 Human cytochrome P450 7B1 (CYP7B1) is a steroidogenic heme-containing monooxygenase primarily expressed in liver and brain. In liver, CYP7B1 7a-hydroxylates substrates 25-hydroxycholesterol and 27-hydroxycholesterol to ... See on Source

jpet.aspetjournals.org

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23/05/2024

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Elucidating the Drug-Drug Interaction Potential of Hydroxychloroquine Metabolites due to Direct and Time-Dependent Inhibition of CYP3A [ASPET 2024 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)]

Abstract ID 93442 Poster Board 037 Aims: Hydroxychloroquine (HCQ) is a safe and effective treatment of rheumatoid arthritis and systemic lupus erythematosus. HCQ is metabolized into three metabolites: desethylhydroxychloroquine (DHCQ), desethylchloroquin... See on Source

jpet.aspetjournals.org

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23/05/2024

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Biotransformation Pathways of 11{beta}-Methyl-19-Nortestosterone and Its Prodrugs: Mechanistic In vitro Studies Unveils Involvement of Polymorphic Intestinal UGT2B17 [ASPET 2024 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)]

Abstract ID 97258 Poster Board 038 Despite the availability of effective female-centric contraceptives, millions of unintended pregnancies are reported annually.1 Recent developments in the realm of oral male contraceptives are viewed as promising steps ... See on Source

jpet.aspetjournals.org

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23/05/2024

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Investigating Tucatinib Metabolism and CYP3A and CYP2C8 Phenotypes in Human Liver Microsomes from African Americans in vitro [ASPET 2024 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)]

Abstract ID 99779 Poster Board 039 Tucatinib is a human epidermal growth factor receptor-2 (HER2) specific tyrosine kinase inhibitor for HER2-positive breast cancer metabolized by cytochrome P450 (CYP) 3A and CYP2C8. The goal of this study was to determi... See on Source

jpet.aspetjournals.org

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23/05/2024

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Non-additivity of the functional properties of P450 enzymes in the human drug-metabolizing ensemble revealed in a study with a series of individual microsomal preparations [ASPET 2024 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)]

Abstract ID 102638 Poster Board 040 Recent advances in studying the effects of hetero-association of multiple cytochrome P450 species reveal a tight functional integration in the P450 ensemble attained through physical interactions between the constituti... See on Source

jpet.aspetjournals.org

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23/05/2024

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Enzyme Kinetics of Benzalkonium Chloride Metabolism in Liver Microsomes [ASPET 2024 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)]

Abstract ID 129282 Poster Board 041 Introduction: Benzalkonium chlorides (BACs) are quaternary ammonium antimicrobials used in disinfectants, consumer products, pharmaceutical formulation, and food processing. Due to this high frequency of exposure, BACs... See on Source

jpet.aspetjournals.org

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23/05/2024

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Visualization of Region-Specific Lipid Alterations in the Mouse Brain in Response to Efavirenz Treatment Using MALDI Mass Spectrometry Imaging [ASPET 2024 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)]

Abstract ID 129701 Poster Board 042 Efavirenz (EFV) is a non-nucleoside reverse transcriptase inhibitor used for human immunodeficiency virus (HIV) treatment in combination with other antiretrovirals such as tenofovir and emtricitabine. Notably, EFV has ... See on Source

jpet.aspetjournals.org

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23/05/2024

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Elucidating the Disposition and Metabolism of Benzalkonium Chloride compounds in C57BL/6 mice [ASPET 2024 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)]

Abstract ID 130932 Poster Board 043 Benzalkonium chlorides (BACs) are quaternary ammonium antimicrobials widely applied in domestic, agricultural, clinical, and industrial settings (e.g., disinfectant sprays, food processing, pharmaceutical formulations,... See on Source

jpet.aspetjournals.org

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23/05/2024

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Bile acids inhibit equilibrative adenosine transport during cholestasis [ASPET 2024 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)]

Abstract ID 131351 Poster Board 044 Arnav A. Joshi, Rajgopal Govindarajan* Bile acids (BAs) impair purinergic signaling during cholestasis with poorly understood mechanisms. Here we investigate the interference of BAs with purine nucleoside transport as ... See on Source

jpet.aspetjournals.org

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23/05/2024

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Targeting Therapy-Induced Senescence: The Role of p21 in Shifting Cellular Fate from Senescence to Apoptosis [ASPET 2024 Annual Meeting Abstract - Cancer Pharmacology]

Abstract ID 87494 Poster Board 045 Therapy-induced senescence (TIS) has become a matter of controversy among scientists over the last decade. There is an evidence that TIS is considered as a mode of cell death, while others see that the promotion of cell... See on Source

jpet.aspetjournals.org

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23/05/2024

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Targeting HUNK: Pharmacological Insights and Therapeutic Implications [ASPET 2024 Annual Meeting Abstract - Cancer Pharmacology]

Abstract ID 90902 Poster Board 046 Ultimately treatment resistance and metastasis are what kill individuals living with breast cancer. Identifying novel, effective treatments to address this issue is of critical importance. Hormonally Upregulated Neu-ass... See on Source

jpet.aspetjournals.org

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23/05/2024

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Cyclin-dependent kinase 4/6 Inhibitor Abemaciclib and Histone deacetylase Inhibitor Panobinostat Treatment Exerts Metabolic Reprogramming of Pancreatic Cancer Cells [ASPET 2024 Annual Meeting Abstract - Cancer Pharmacology]

Abstract ID 93056 Poster Board 047 Pancreatic cancer being the deadliest among solid tumors, holds multiple challenges with an overall 5-year survival rate of only 12%. Aggressive invasive and metastatic properties of this cancer along with delayed detec... See on Source

jpet.aspetjournals.org

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23/05/2024

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Adavosertib targets Cell Cycle Regulator WEE1 and Inhibits Pediatric Neuroblastoma Growth [ASPET 2024 Annual Meeting Abstract - Cancer Pharmacology]

Abstract ID 93496 Poster Board 048 Purpose: High-risk neuroblastoma (NB) is a pediatric cancer that arises during the sympathetic nervous system’s development. Despite recent advancements in treatment strategies involving intensive chemotherapies, ... See on Source

jpet.aspetjournals.org

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23/05/2024

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Epigenetic Targeting of DNMT1 Inhibits Neuroblastoma Growth: an in vitro and in vivo study [ASPET 2024 Annual Meeting Abstract - Cancer Pharmacology]

Abstract ID 97834 Poster Board 049 Purpose: Neuroblastoma (NB) is a solid tumor that develops from premature nerve cells of the sympathetic nervous system and is reported as the most common cancer in children younger than 1 year. Despite advanced treatme... See on Source

jpet.aspetjournals.org

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23/05/2024

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Cytotoxic Synergy in Dual Inhibition of Nek2 and EGFR Kinases in Glioblastoma Cells [ASPET 2024 Annual Meeting Abstract - Cancer Pharmacology]

Abstract ID 97995 Poster Board 050 Glioblastoma (GBM), also known as Grade IV astrocytoma, is an aggressive form of brain tumor which shows strong resistance to chemotherapy and radiotherapy. The median survival time is only 12-15months with the current ... See on Source

jpet.aspetjournals.org

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23/05/2024

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ABCA13 Regulation of the Hedgehog pathway [ASPET 2024 Annual Meeting Abstract - Cancer Pharmacology]

Abstract ID 98092 Poster Board 051 The hedgehog (Hh) pathway is a key developmental pathway that plays an important role in vertebrate embryonic development. Altered Hh pathway activity can lead to a variety of diseases including Sonic Hedgehog Medullobl... See on Source

jpet.aspetjournals.org

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23/05/2024

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Roles of Hepatic Bile Acid Transporters in Hepatocellular Carcinoma [ASPET 2024 Annual Meeting Abstract - Cancer Pharmacology]

Abstract ID 98689 Poster Board 052 Objective: Hepatocellular carcinoma (HCC) is the most common primary liver malignancy that occurs predominantly in patients with underlying chronic liver disease and cirrhosis. Sodium-taurocholate co-transporting polype... See on Source

jpet.aspetjournals.org

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23/05/2024

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A CRISPR Screen Identifies Novel Factors Contributing to AML Metabolic State Affecrting Clofarabine Cytotoxicity [ASPET 2024 Annual Meeting Abstract - Cancer Pharmacology]

Abstract ID 99092 Poster Board 053 Acute myeloid leukemia (AML) is an aggressive and heterogenous hematologic malignancy. AML’s heterogeneity in part contributes to a poor 5-year survival rate of only about 40%. Bulk AML is thought to utilize both ... See on Source

jpet.aspetjournals.org

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23/05/2024

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Avaren-Fc: A Novel Immunotherapeutic Strategy to Target High-Mannose-Glycans in Ovarian Cancer [ASPET 2024 Annual Meeting Abstract - Cancer Pharmacology]

Abstract ID 125017 Poster Board 054 Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. According to the NCI Surveillance, Epidemiology, and End Results Program, the overall 5-year survival rate was 50.8% and a late-stage diagnosis s... See on Source

jpet.aspetjournals.org

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23/05/2024

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ROR1 Epigenetic Grip on CREB3L1, a Tumor Suppressor in Triple-Negative Breast Cancer [ASPET 2024 Annual Meeting Abstract - Cancer Pharmacology]

Abstract ID 128510 Poster Board 055 Over 300,000 new cases of invasive breast cancer are projected in the United States alone for 2024. Triple-Negative breast cancer (TNBC) is the most aggressive form of breast cancer. It is also the most difficult to tr... See on Source

jpet.aspetjournals.org

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23/05/2024

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A New Strategy to Boost the Efficacy of Melanoma Immune Checkpoint Inhibitor by Targeting HDAC4 to Modify the T-cell Inflamed Signature [ASPET 2024 Annual Meeting Abstract - Cancer Pharmacology]

Abstract ID 128681 Poster Board 056 Melanoma remains one of the difficult malignancies to treat, due to its ability to evade anti-tumor immune responses via employing tolerance mechanisms such as negative immune checkpoint molecules. While immune checkpo... See on Source

jpet.aspetjournals.org

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23/05/2024

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The Role of the Mevalonate pathway in Post-translational Modifications of PD-L1 [ASPET 2024 Annual Meeting Abstract - Cancer Pharmacology]

Abstract ID 129185 Poster Board 057 Background: The binding of PD-L1 on the surface of tumor cells to PD-1 on T cells prevents T-cell-mediated anti-cancer immune responses. The use of immunotherapies targeting the PD-L1/PD-1 interaction has improved surv... See on Source

jpet.aspetjournals.org

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23/05/2024

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The Effects of Mibefradil in African American Triple Negative Breast Cancer Cells [ASPET 2024 Annual Meeting Abstract - Cancer Pharmacology]

Abstract ID 129904 Poster Board 058 More than one in ten women are affected globally by breast cancer (BC). Occurrence of BC differs among women of all ethnic groups and ages. The morbidity rate is the same in both European American (EA) and African Amer... See on Source

jpet.aspetjournals.org

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23/05/2024

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Amphotericin-A21 produces antiproliferative effects through modulating EGFR expression in glioblastoma multiforme cells [ASPET 2024 Annual Meeting Abstract - Cancer Pharmacology]

Abstract ID 131002 Poster Board 059 Glioblastoma multiforme (GBM) is the most frequent malignant astrocytic tumor of the central nervous system (CNS). The survival time of patients with GBM is 8 to 15 months. Our research group has developed a semi-synth... See on Source

jpet.aspetjournals.org

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23/05/2024

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Characterizing Imatinibs Pharmacokinetics and Impact on Neuronal p-ERK Signaling [ASPET 2024 Annual Meeting Abstract - Cancer Pharmacology]

Abstract ID 131233 Poster Board 060 Objectives: Chemotherapy-related cognitive impairment (CRCI) is an adverse effect associated with both cytotoxic and targeted chemotherapy, including select tyrosine kinase inhibitors (TKIs). Based on recent clinical r... See on Source

jpet.aspetjournals.org

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23/05/2024

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Advancing Clinical Pharmacology through Microgravity: Insights and Framework from Space-Based Research Programs [ASPET 2024 Annual Meeting Abstract - Cancer Pharmacology]

Abstract ID 128984 Poster Board 061 Introduction: The vastness of space offers an unparalleled laboratory for clinical pharmacology research, providing unique conditions to conduct drug discovery programs, clinical research initiatives, and trials in way... See on Source

jpet.aspetjournals.org

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23/05/2024

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Sodium butyrate alleviates chemotherapy induced gastrointestinal toxicity [ASPET 2024 Annual Meeting Abstract - Cancer Pharmacology]

Abstract ID 94122 Poster Board 062 Diarrhea is a prevalent side effect of chemotherapeutic treatment that can result in reduction of quality of life, dose limitation, and death. Irinotecan is a widely used chemotherapeutic in the treatment of unresectabl... See on Source

jpet.aspetjournals.org

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23/05/2024

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Asthma associated vascular endothelial dysfunction and the role of sex hormones in ovariectomized and castrated C57/BL6 mice [ASPET 2024 Annual Meeting Abstract - Cardiovascular Pharmacology]

Abstract ID 87562 Poster Board 063 Background: Asthma is a complex airway inflammatory disorder that affects people of all ages, sexes, races, and ethnicities. Interestingly, asthma is more likely to occur in prepubescent males than females, however, thi... See on Source

jpet.aspetjournals.org

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23/05/2024

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Cardiomyocyte-specific deletion of adhesion G protein-coupled receptor F5 (ADGRF5) increases susceptibility to stress and arrhythmia [ASPET 2024 Annual Meeting Abstract - Cardiovascular Pharmacology]

Abstract ID 94153 Poster Board 064 G-Protein Coupled Receptors (GPCR) represent the largest family of cell surface receptors in the human body and serve as targets for more than 30% of all approved drugs. Adhesion GPCRs (AGPCR) are an understudied GPCR f... See on Source

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23/05/2024

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Contribution of High Mobility Group Box 1 to Nicotine-Induced Podocyte Injury and Glomerular Sclerosis [ASPET 2024 Annual Meeting Abstract - Cardiovascular Pharmacology]

Abstract ID 95360 Poster Board 065 Cigarette smoking, a well-established risk factor for many diseases, plays a pivotal role in the incidence and progression of renal dysfunction. Smoking associated renal damage bears distinct physiological correlations ... See on Source

jpet.aspetjournals.org

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23/05/2024

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Occurrence and Impact of Invasive Candidemia and Antimicrobial Resistance on Clinical Outcomes in Patients on Extracorporeal Membrane Oxygenation [ASPET 2024 Annual Meeting Abstract - Cardiovascular Pharmacology]

Abstract ID 130283 Poster Board 066 Introduction: Whether extracorporeal membrane oxygenation (ECMO) favours the development of candidemia and antimicrobial resistance, and their association with patients’ outcomes remain currently unanswered quest... See on Source

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23/05/2024

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MARY1 Promotes Recovery from Acute Kidney Injury through Induction of Mitochondrial Biogenesis [ASPET 2024 Annual Meeting Abstract - Cardiovascular Pharmacology]

Abstract ID 95561 Poster Board 067 Background: Acute kidney injury (AKI) is defined as a sudden and rapid loss of kidney function which is accompanied by elevated serum creatinine and mitochondrial dysfunction. Ischemia reperfusion (I/R) injury, sepsis, ... See on Source

jpet.aspetjournals.org

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23/05/2024

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Age- and Sex- Specific Aberrations of Arterial Pressure Control in Prediabetes: What does Machine Learning reveal about Frequency Domain Analysis of Blood Pressure? [ASPET 2024 Annual Meeting Abstract - Cardiovascular Pharmacology]

Abstract ID 95800 Poster Board 068 The prediabetic state is associated with insidious cardiovascular (CV) disease which often goes uncharacterized due to its subclinical nature. Early CV risk appraisal in prediabetes remains an unmet goal because of the ... See on Source

jpet.aspetjournals.org

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23/05/2024

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miR-146a; a potential link connecting shear stress-induced activation of the pro-inflammatory and pro-proliferative Osteopontin & TLR-4 pathways [ASPET 2024 Annual Meeting Abstract - Cardiovascular Pharmacology]

Abstract ID 97368 Poster Board 069 Introduction: MicroRNA-146a (miR-146a) is a key anti-atherogenic shear-sensitive microRNA that can modulate vascular inflammation through suppression of pro-inflammatory TLR-4 pathway. Our previous preliminary studies s... See on Source

jpet.aspetjournals.org

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23/05/2024

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Enhancement of ANGPTL4 exacerbates post-ischemic myocardial ferroptosis and cellular injury in diabetic conditions via impairing AKT/AMPK signaling [ASPET 2024 Annual Meeting Abstract - Cardiovascular Pharmacology]

Abstract ID 97790 Poster Board 070 Background: Myocardial infarction as a result of ischemic heart disease is the primary cause of death in patients with type 2 diabetes mellitus (T2DM). Reperfusion therapy restores blood flow, but paradoxically exacerba... See on Source

jpet.aspetjournals.org

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23/05/2024

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Investigation of the role of human CYP2J2*7 in proarrhythmia [ASPET 2024 Annual Meeting Abstract - Cardiovascular Pharmacology]

Abstract ID 102601 Poster Board 071 Cardiac cytochrome P450 2J2 (CYP2J2) is pivotal in metabolizing endogenous arachidonic acid (AA) to cardioprotective epoxyeicosatrienoic acids (EETs) and plays a regulatory role in cardiac electrophysiology. Our labora... See on Source

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23/05/2024

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Loss of B56{alpha} enhances vascular relaxation after activation of PP2A by Fingolimod [ASPET 2024 Annual Meeting Abstract - Cardiovascular Pharmacology]

Abstract ID 128553 Poster Board 072 Introduction: Protein phosphatase 2A (PP2A) regulates cellular functions by dephosphorylation of target proteins. Dysregulation of PP2A is implicated in various diseases, making small molecules activating PP2A (SMAPs) ... See on Source

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23/05/2024

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Central Inflammatory and Oxidative Signals Contribute to the Morphine Exacerbation of Cardiovascular Hallmarks of Sepsis in Rats [ASPET 2024 Annual Meeting Abstract - Cardiovascular Pharmacology]

Abstract ID 95481 Poster Board 073 Sepsis remains one of the most serious and possibly fatal complications encountered in intensive care units. Considering the frequent use of narcotic analgesics in this setting, we investigated whether cardiovascular an... See on Source

jpet.aspetjournals.org

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23/05/2024

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Adenosine A3 Receptors Offset the Nicotine Amelioration of Sepsis-Induced Brainstem Inflammation and Depressed Reflex Bradycardia [ASPET 2024 Annual Meeting Abstract - Cardiovascular Pharmacology]

Abstract ID 87640 Poster Board 074 We have previously reported that the central cholinergic pathway improves arterial baroreflex dysfunction induced by sepsis. Given the role of central adenosinergic neurotransmission in baroreflex control, we tested the... See on Source

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23/05/2024

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Betulin, a Compound Isolated from Crinum asiaticum Bulbs Exerted Anti-Silicosis and Pulmonoprotective Effects Through the Inhibition of NF-{kappa}B activation in Rat model [ASPET 2024 Annual Meeting Abstract - Drug Discovery and Development]

Abstract ID 85033 Poster Board 075 Silicosis is an interstitial lung disease that causes shortness of breath, cough, fever, and blue skin and causes a heavy burden to patients both physically and mentally. Silicosis at the moment has no effective treatme... See on Source

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23/05/2024

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An Agonist Concentration Biased NMDA Receptor Modulator Produces Analgesic Activity in Experimental Animals [ASPET 2024 Annual Meeting Abstract - Drug Discovery and Development]

Abstract ID 87541 Poster Board 076 Pain is the most common reason for human adults to seek medical care. Pain restricts daily life activities, causes opioid addiction and depression, and affects quality of life. Imbalanced activity of NMDA glutamate rece... See on Source

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23/05/2024

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Anti-Ulcerative Effect of Hydroethanolic Root Extract of Ficus capensis in Sprague Dawley Rats [ASPET 2024 Annual Meeting Abstract - Drug Discovery and Development]

Abstract ID 90351 Poster Board 077 Background: Ulcerative colitis is a chronic debilitating inflammatory disease that affects the colon and the rectum and typically involves the innermost lining or mucosal membrane. Due to unwanted effects of synthetic a... See on Source

jpet.aspetjournals.org

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23/05/2024

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Deuterated Buprenorphine Mitigates Fentanyl Effects in Pregnant Rats [ASPET 2024 Annual Meeting Abstract - Drug Discovery and Development]

Abstract ID 90377 Poster Board 078 During the 12-month period ending in April 2021, opioid-related deaths, primarily from fentanyl, reached an all-time high in the US, affecting up to 100,000 people annually. People undergoing medication-assisted treatme... See on Source

jpet.aspetjournals.org

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23/05/2024

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Anti-cancer and Anti-inflammatory Properties of Ziziphus Nummularia Ethanolic Extract in Triple Negative Human Breast Cancer Cells MDA-MB-231 [ASPET 2024 Annual Meeting Abstract - Drug Discovery and Development]

Abstract ID 91433 Poster Board 079 Breast cancer continues to be one of the most diagnosed cancers in women worldwide with triple-negative breast cancer (TNBC) that makes up approximately 15% to 20%. TNBC is challenging to treat because it does not respo... See on Source

jpet.aspetjournals.org

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23/05/2024

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In silico, in vitro and in vivo antiplasmodial activity of {beta}-amyrin and its potential synergistic effect when co-administered with artesunate [ASPET 2024 Annual Meeting Abstract - Drug Discovery and Development]

Abstract ID 91566 Poster Board 080 Malaria presents a serious health concern worldwide. Combination therapy has been adopted to curb the development of resistance, and this calls for the urgent search for newer drug candidates to be used either in new dr... See on Source

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23/05/2024

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Green Silver Nanoparticles Synthesized from Moringa Oleifera Stem Bark Elicits Effective Antidiabetic Effect in Alloxan-Induced (Type I) Diabetic Wistar Rats [ASPET 2024 Annual Meeting Abstract - Drug Discovery and Development]

Abstract ID 92638 Poster Board 081 The use of nanomaterials in antidiabetic research is on the rise because of their special qualities, like their small size, biocompatibility, and capacity to penetrate cell membranes for drug delivery. In this study, th... See on Source

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23/05/2024

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The anticancer and anti-inflammatory activities of Halodule uninervis ethanolic extract: Pharmaco-molecular mechanism of action and bioactive constituents [ASPET 2024 Annual Meeting Abstract - Drug Discovery and Development]

Abstract ID 93445 Poster Board 082 Background: Breast cancer is the second leading cause of cancer-related morbidity and mortality in the world. More specifically, triple negative breast cancer (TNBC) is the most aggressive subtype and accounts for 10-20... See on Source

jpet.aspetjournals.org

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23/05/2024

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Computational Screening of an Isolated HerbalCcompound, Carveol on GPC-1 Protein Receptors in Prostate Cancer: A Molecular Docking Study [ASPET 2024 Annual Meeting Abstract - Drug Discovery and Development]

Abstract ID 94158 Poster Board 083 Background: Prostate cancer (PC) remains the most prevalent neoplasia in Western countries, presenting a significant threat to male mortality. Glypicans (GPCs), a subgroup of Heparan Sulphate Proteoglycans (HSPCs), are ... See on Source

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23/05/2024

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Structural Analysis of Delta Opioid Receptor Ligands for Chronic Pain Therapeutics [ASPET 2024 Annual Meeting Abstract - Drug Discovery and Development]

Abstract ID 95191 Poster Board 084 Chronic pain is highly prevalent and is one of the most common reasons adults seek medical attention. Unfortunately, current therapeutics to treat this type of pain are limited due to low efficacy and/or high side effec... See on Source

jpet.aspetjournals.org

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23/05/2024

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Activation of neutrophil elastase-related serine proteases in myelomonocytic cells [ASPET 2024 Annual Meeting Abstract - Drug Discovery and Development]

Abstract ID 97018 Poster Board 085 Elastase, proteinase 3, cathepsin G and NSP4 (Neutrophil Serine Protease 4) are pro-inflammatory serine proteases found within the granules of promyelocytes during neutrophil differentiation in the bone marrow. The vast... See on Source

jpet.aspetjournals.org

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23/05/2024

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Targeting Proprotein Convertases and Follicle Rupture to Identify Non-hormonal Contraceptive Candidates [ASPET 2024 Annual Meeting Abstract - Drug Discovery and Development]

Abstract ID 97333 Poster Board 086 Traditional female contraceptives are based on steroid hormones such as progestin, which block ovulation but also cause undesired side effects, including hormone-related cancers, depression, stroke, and obesity. There i... See on Source

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23/05/2024

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Serendipitous Discovery of Novel 5-HT2AR Positive Allosteric Modulators (PAMs) Derived From 5-HT2CR PAM Scaffolds [ASPET 2024 Annual Meeting Abstract - Drug Discovery and Development]

Abstract ID 98540 Poster Board 087 AIMS: The 5-HT2A receptor (5-HT2AR) is a promising therapeutic target for neuropsychiatric disorders. There is renewed therapeutic interest in psychedelic 5-HT2AR agonists; however, their abuse liability and ancillary p... See on Source

jpet.aspetjournals.org

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23/05/2024

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Catestatin, its mimetic, and a natural variant improve insulin sensitivity in diet-induced obese mice: potential therapeutical implications [ASPET 2024 Annual Meeting Abstract - Drug Discovery and Development]

Abstract ID 99340 Poster Board 088 Objective: In 2019, 11.3% Americans had type 2 diabetes (T2D), which contributed to $412.9 billion in healthcare costs. Insulin resistance (IR) is the hallmark of obesity and T2D. While hepatic IR increases the risk of ... See on Source

jpet.aspetjournals.org

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23/05/2024

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Examining a Unique Cysteine Residue in Regulating Differences Between ERK1 and ERK2 Signaling and Potential as Novel Therapeutic Targets [ASPET 2024 Annual Meeting Abstract - Drug Discovery and Development]

Abstract ID 99884 Poster Board 089 The extracellular signal-regulated kinase 1 and 2 (ERK1/2) signaling pathway is a well-studied kinase signaling pathway involved in cell growth and proliferation. Dysregulation of this pathway is responsible for uncontr... See on Source

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23/05/2024

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Utilizing Ancestral Sequence Reconstruction to Generate a Novel Recombinant Humanized L-Asparaginase with Enhanced Chemotherapeutic Properties [ASPET 2024 Annual Meeting Abstract - Drug Discovery and Development]

Abstract ID 100580 Poster Board 090 L-asparaginase (L-ASNase) has been a critical component of acute lymphoblastic leukemia (ALL) chemotherapy regimens for several decades, however, recent preclinical data has shown that L-ASNase may also be beneficial i... See on Source

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23/05/2024

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Inhibition of the Cysteine Protease Cathepsin K Attenuates Diabetic Neuropathic Pain [ASPET 2024 Annual Meeting Abstract - Drug Discovery and Development]

Abstract ID 102312 Poster Board 091 Background and Aim: Diabetes mellitus is escalating at epidemic proportions worldwide, posing a huge clinical and economic burden on society. Diabetic peripheral neuropathy (DPN) is a painful and debilitating complicat... See on Source

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23/05/2024

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Toxicology testing in minipigs of a heroin vaccine intended for clinical treatment of opioid use disorder [ASPET 2024 Annual Meeting Abstract - Drug Discovery and Development]

Abstract ID 125919 Poster Board 092 A heroin vaccine (M-sKLH adsorbed to aluminum and adjuvanted with a TLR7/8 agonist INI-4001) is being developed for clinical evaluation to treat opioid use disorder (OUD) and has shown pre-clinical efficacy in rodents.... See on Source

jpet.aspetjournals.org

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23/05/2024

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Design, Synthesis, and Biological Evaluation of Substituted Hydroxyquinolinone Compounds as 20S Proteasome Enhancers [ASPET 2024 Annual Meeting Abstract - Drug Discovery and Development]

Abstract ID 128480 Poster Board 093 The 20S proteasome is a key component in cellular proteostasis and assists the cell in maintaining proper levels of intrinsically disordered proteins (IDPs). Dysregulation of 20S proteasome-mediated proteolytic degrada... See on Source

jpet.aspetjournals.org

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23/05/2024

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Mechanistic Insights into Xanthohumol-Induced Apoptosis and Cytokine Modulation in Multiple Myeloma with a Focus on Nanoparticle Targeting Strategies [ASPET 2024 Annual Meeting Abstract - Drug Discovery and Development]

Abstract ID 129189 Poster Board 094 Multiple myeloma (MM) is characterized by a malignancy of terminally differentiated B lymphocytes within the bone marrow microenvironment (BME). The BME fosters the proliferation of MM cells and enhances their resistan... See on Source

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23/05/2024

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Inhibiting the Cytotoxic Effect of Tubulin Polymerization-Promoting Protein (TPPP/p25{alpha}) Induced {alpha}-synuclein Aggregates Via 20S Proteasome Enhancement [ASPET 2024 Annual Meeting Abstract - Drug Discovery and Development]

Abstract ID 129750 Poster Board 095 Multiple System Atrophy (MSA) belongs to a subset of Neurodegenerative Diseases (NDs) known as synucleinopathies, which includes Parkinson’s disease (PD) and Dementia with Lewy Bodies (DLB). The accumulation of a... See on Source

jpet.aspetjournals.org

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23/05/2024

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MAL-PD Theory/Algorithm Guided Clinical Protocol Design for Computerized Data Analysis and Digital Conclusions in Drug Evaluations for Single Drugs and Combinations [ASPET 2024 Annual Meeting Abstract - Drug Discovery and Development]

Abstract ID 131292 Poster Board 096 Mathematical system analysis on mass-action law (MAL) and enzyme model resulted in the derivation of over 300 reaction-rate equations, which can be deduced into unified general MAL-dynamics theories/algorithms for comp... See on Source

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23/05/2024

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Investigating the Role of Alpha-7 Nicotinic Acetylcholine Receptors in Myeloid Lineage Cells in Acute and Chronic Inflammatory Pain [ASPET 2024 Annual Meeting Abstract - Neuropharmacology]

Abstract ID 90358 Poster Board 097 Alpha-7 nicotinic acetylcholine receptors (α7-nAChRs) have been shown to play a role in pain and inflammation. These receptors are expressed in macrophages and other myeloid lineage cells, which mediate the endoge... See on Source

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23/05/2024

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Evaluation of the Reinforcing Effects of the Novel Dopamine Transport Inhibitor JJC8-091 in Monkeys [ASPET 2024 Annual Meeting Abstract - Neuropharmacology]

Abstract ID 87710 Poster Board 098 While there are no FDA-approved treatments for cocaine use disorder (CUD), one pharmacological strategy is to utilize DA transporter (DAT) inhibitors that could block the effects of cocaine but may not have abuse liabil... See on Source

jpet.aspetjournals.org

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23/05/2024

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Low Dose Methylphenidate Modulates Risky Decision Making and Prefrontal Catecholamine Regulation in a Sex-Dependent Manner Following Repeated Mild Traumatic Brain Injury [ASPET 2024 Annual Meeting Abstract - Neuropharmacology]

Abstract ID 80090 Poster Board 099 Head trauma impairs higher-order decision making processes mediated within the prefrontal cortex (PFC) of the brain and often leads to increased risk-taking behavior. Mild forms of TBI (mTBI), often labeled concussion, ... See on Source

jpet.aspetjournals.org

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23/05/2024

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Behavioral Effects of Gabapentin and Heroin in Rats [ASPET 2024 Annual Meeting Abstract - Central Nervous System Pharmacology - Behavioral]

Abstract ID 87315 Poster Board 100 Gabapentin is a widely prescribed medication approved for the treatment of some seizure and neuropathic pain disorders and has long been considered a relatively safe drug with minimal toxicity or abuse potential. Howeve... See on Source

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23/05/2024

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Characterizing a Monoclonal Antibody for the Reversal and Prevention of Fentanyl-Induced Hypoventilation in Rhesus Monkeys [ASPET 2024 Annual Meeting Abstract - Central Nervous System Pharmacology - Behavioral]

Abstract ID 90672 Poster Board 101 Nearly 70% of drug overdose deaths in 2022 involved fentanyl or fentanyl analogs. Due to a significant increase in the presence of fentanyls in the opioid and non-opioid drug supply (e.g., stimulants, illicitly manufact... See on Source

jpet.aspetjournals.org

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23/05/2024

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Buprenorphrine Alters Anxiety-like Behavior in C57BL/6J (B6) Mice as a Function of Dose, Sex, and Obesity [ASPET 2024 Annual Meeting Abstract - Central Nervous System Pharmacology - Behavioral]

Abstract ID 91916 Poster Board 102 The opioid buprenorphine is used for medication assisted treatment of opioid use disorder (10.1001/jamanetworkopen.2023.34540). Depression and anxiety can be comorbid, and buprenorphine reduces fear recognition in human... See on Source

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23/05/2024

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Discriminative Stimulus Effects of Ethanol, Alprazolam and Pentobarbital in Rats [ASPET 2024 Annual Meeting Abstract - Central Nervous System Pharmacology - Behavioral]

Abstract ID 92162 Poster Board 103 Background: The GABAA receptor complex has allosteric binding sites for drugs from drug classes such as benzodiazepines, barbiturates, and alcohols. This study was done to determine whether drugs from these different cl... See on Source

jpet.aspetjournals.org

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23/05/2024

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Evaluation of {alpha}-terpineol Attenuation of Precipitated Nicotine Withdrawal Behaviors in Mice [ASPET 2024 Annual Meeting Abstract - Central Nervous System Pharmacology - Behavioral]

Abstract ID 92587 Poster Board 104 Tobacco is the leading cause of preventable death in the world, and tobacco-related illness accounts for 10% of worldwide mortality. Tobacco contains nicotine, a highly addictive alkaloid. Individuals attempting to quit... See on Source

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23/05/2024

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Effects of Bupropion on Pain-Related Depression of Shredding in Male and Female Mice [ASPET 2024 Annual Meeting Abstract - Central Nervous System Pharmacology - Behavioral]

Abstract ID 93993 Poster Board 105 A key goal in preclinical pain research is understanding the underlying mechanisms of pain and pain-disrupted behaviors to improve treatments for pain. Past studies suggest dopamine plays a role in pain-related disrupti... See on Source

jpet.aspetjournals.org

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23/05/2024

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A Quantitative Model of a Substitution Therapy Using Cocaine Self-Administration Behavior in Rats [ASPET 2024 Annual Meeting Abstract - Central Nervous System Pharmacology - Behavioral]

Abstract ID 94483 Poster Board 106 According to a 2021 national survey on drug use and health, approximately 1.4 million people aged 12 or older had a cocaine disorder and about 4.8 million people among that demographic had reported using cocaine in the ... See on Source

jpet.aspetjournals.org

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23/05/2024

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Effects of the Veterinary Anesthetic Xylazine on the Discriminative Stimulus Effects of the Opioid Agonist Fentanyl in Rats [ASPET 2024 Annual Meeting Abstract - Central Nervous System Pharmacology - Behavioral]

Abstract ID 94514 Poster Board 107 Fentanyl adulterated with the alpha2-adrenoreceptor agonist xylazine is becoming increasingly more common and further escalating the opioid crisis in many major cities. Some people who inject drugs report xylazine exten... See on Source

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23/05/2024

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Bypassing UCP-1 Mediated Thermogenesis Ameliorates Cognitive Impairment in Early Prediabetes [ASPET 2024 Annual Meeting Abstract - Central Nervous System Pharmacology - Behavioral]

Abstract ID 96579 Poster Board 108 Prediabetes is an early stage of metabolic dysfunction characterized by impaired glucose tolerance and marked insulin resistance associated with an increased risk of vascular diseases. Notably, a strong correlation betw... See on Source

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23/05/2024

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Effects of Nerve Agent Analogs on Memorial, Attentional, and Interoceptive Processes: Insights into the Cognitive Consequences of Chemical Warfare [ASPET 2024 Annual Meeting Abstract - Central Nervous System Pharmacology - Behavioral]

Abstract ID 96747 Poster Board 109 As one of the most toxic forms of chemical warfare agents, nerve agents cause death just minutes after exposure by irreversibly inhibiting acetylcholinesterase (AChE) activity in the central and peripheral nervous syste... See on Source

jpet.aspetjournals.org

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23/05/2024

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Oral Oxycodone Self Administration in Rats with a History of Responding Under a Multiple Schedule for Ethanol and Food or Oxycodone and Food [ASPET 2024 Annual Meeting Abstract - Central Nervous System Pharmacology - Behavioral]

Abstract ID 97121 Poster Board 110 For people who struggle with alcohol-use disorder (AUD) or opioid-use disorder (OUD), the co-administration of other abused substances, or polysubstance abuse, is common. However, preclinical studies that assess the co-... See on Source

jpet.aspetjournals.org

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23/05/2024

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The BDFN-TrkB-KCC2 pathway as a potential treatment target for modulating alcohol consumption [ASPET 2024 Annual Meeting Abstract - Central Nervous System Pharmacology - Behavioral]

Abstract ID 98214 Poster Board 111 Brain-derived neurotrophic factor (BDNF) is involved in various physiological processes. Its main receptor in the central nervous system is tyrosine receptor kinase B (TrkB), and the main ligand for TrkB in the central ... See on Source

jpet.aspetjournals.org

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23/05/2024

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The Effects of Cytokine Receptor Antagonism in the Locus Coeruleus on Stress-related Behaviors in Females [ASPET 2024 Annual Meeting Abstract - Central Nervous System Pharmacology - Behavioral]

Abstract ID 99689 Poster Board 112 It is estimated that 8 million deaths/year worldwide are due to mental health disorders. While this is problematic to society as a whole, women are disproportionally affected with over twice the rate of post-traumatic s... See on Source

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23/05/2024

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Monkey Models of Polysubstance Misuse: Reinforcing Effects of Cocaine With and Without Alcohol or Nicotine Co-Use [ASPET 2024 Annual Meeting Abstract - Central Nervous System Pharmacology - Behavioral]

Abstract ID 100775 Poster Board 113 Cocaine use disorder (CUD) continues to be a public health crisis, with no FDA-approved treatments. Estimates indicate that <80% of people who use cocaine co-use nicotine and nearly 90% of people with CUD co-use alc... See on Source

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23/05/2024

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Knockdown of a GABAA receptor auxiliary protein using RVG-DsiRNA decreases the potency of ethanols, but not Alprazolams, effects on a repeated acquisition procedure [ASPET 2024 Annual Meeting Abstract - Central Nervous System Pharmacology - Behavioral]

Abstract ID 101466 Poster Board 114 Background: A GABAA receptor-associated protein, Shisa7, has been shown to affect GABAA subunit composition and kinetics. GABAA positive allosteric modulators, ethanol and alprazolam, were administered to rats during a... See on Source

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23/05/2024

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Systemic Administration of the 5-HT1b Antagonist SB-216641 Prior to Acute Stress Exposure in Rats Mildly Prevents Stress-induced Behavioral Performance Dysregulations [ASPET 2024 Annual Meeting Abstract - Central Nervous System Pharmacology - Behavioral]

Abstract ID 127259 Poster Board 115 FDA-approved pharmacotherapies that treat or prevent the vast array of behavioral performance dysregulations observed in ASR (acute stress reactions) and/or ASD (acute stress disorder) are sorely needed. Previous findi... See on Source

jpet.aspetjournals.org

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23/05/2024

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Identification of Behavioral Patterns That Contribute to Emesis through Multiple Linear Regression of Spontaneous Behavior upon Motion Sickness in Suncus Murinus [ASPET 2024 Annual Meeting Abstract - Central Nervous System Pharmacology - Behavioral]

Abstract ID 130306 Poster Board 116 Introduction: In humans, motion sickness (MS) is a common but complex syndrome characterized by a cluster of signs and symptoms including cold sweating, facial pallor, drowsiness, hypersalivation, nausea, vomiting and ... See on Source

jpet.aspetjournals.org

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23/05/2024

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Memantine Effects on Amyloid Plaque Load and Cognition in APP/SP1 Transgenic Mice [ASPET 2024 Annual Meeting Abstract - Neuropharmacology]

Abstract ID 91679 Poster Board 117 Background: In earlier studies, the effects of various drugs were tested on wild-type mice using a Barnes Maze to assess spatial learning and memory by measuring time and distance to enter an Escape Box (EsB). Neuropath... See on Source

jpet.aspetjournals.org

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23/05/2024

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Regulated Trafficking of GABA Transporters, GAT1 and GAT3, in Response to Methamphetamine Through the Trace Amine Associated Receptor, TAAR1 [ASPET 2024 Annual Meeting Abstract - Neuropharmacology]

Abstract ID 92456 Poster Board 118 GABA dysregulation has been implicated in a variety of conditions, from epilepsy to schizophrenia. The main GABA transporters in the CNS, GAT1 and GAT3, are responsible for the maintenance of inhibition throughout the b... See on Source

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23/05/2024

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Developmental Impacts of Adolescent Intermittent Nicotine Vapor Exposure on the Murine Hippocampus [ASPET 2024 Annual Meeting Abstract - Neuropharmacology]

Abstract ID 92515 Poster Board 119 Electronic cigarette (e-cig) use is rapidly rising, especially among adolescents and younger adults. Despite their development as a smoking cessation aid, young adult (18-24 yo) e-cig users are generally also "never smo... See on Source

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23/05/2024

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Elucidating the Mechanism of the Spinal Effects by VGF-derived Peptide TLQP-62 [ASPET 2024 Annual Meeting Abstract - Neuropharmacology]

Abstract ID 92776 Poster Board 120 Introduction: VGF (non-acronymic) is a neurosecretory protein implicated in neuroplasticity associated with depression, learning, memory, and chronic pain. We previously demonstrated that VGF-derived peptides are involv... See on Source

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23/05/2024

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Vaporizing Adolescence: Determining the Neurobiological Consequences of Adolescent Vaping on the Prefrontal Cortex, Nucleus Accumbens, and Ventral Tegmental Area [ASPET 2024 Annual Meeting Abstract - Neuropharmacology]

Abstract ID 94045 Poster Board 121 Electronic nicotine delivery systems (ENDS) are distinctly different from combustible cigarettes due to the availability of flavor options. This key difference has contributed to a high degree of popularity among adoles... See on Source

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23/05/2024

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Analyzing sex differences in how reduced function of plasma membrane monoamine transporters (PMAT) in mice affects learning to work for positive reinforcers [ASPET 2024 Annual Meeting Abstract - Neuropharmacology]

Abstract ID 94463 Poster Board 122 Plasma membrane monoamine transporter (PMAT, Slc29a4) is a low affinity, high capacity monoamine neurotransmitter transporter of dopamine and serotonin. Around 30% of humans have a PMAT polymorphism associated with redu... See on Source

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23/05/2024

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Glial Glutamate Transporter Activator Prevents Inflammatory Pain and Major Depressive Disorder in a Mouse Model of Inflammation Induced by Lipopolysaccharide [ASPET 2024 Annual Meeting Abstract - Neuropharmacology]

Abstract ID 95168 Poster Board 123 Inflammatory pain and major depressive disorder (MDD) commonly co-exist affecting millions of people worldwide with significant socioeconomic impact. Emerging evidence suggests that increased inflammatory mediators can ... See on Source

jpet.aspetjournals.org

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23/05/2024

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Comparative Analysis of Dopamine Neuron Activity in Pavlovian Versus Non-Contingent Methamphetamine Exposure [ASPET 2024 Annual Meeting Abstract - Neuropharmacology]

Abstract ID 95965 Poster Board 124 There is a notable increase in methamphetamine abuse. Despite this increase, the distinct impacts of environmentally associated (Pavlovian) and non-contingent (uncoupled) methamphetamine exposure on the activity of midb... See on Source

jpet.aspetjournals.org

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23/05/2024

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Analogs of {alpha}-conotoxin PnIC are selective for {alpha}7{beta}2 over {alpha}7-only subtype nicotinic acetylcholine receptors [ASPET 2024 Annual Meeting Abstract - Neuropharmacology]

Abstract ID 96289 Poster Board 125 Objective/Aim/Hypothesis: The objective of this work is to discover and characterize the first ligands able to identify selectively nicotinic acetylcholine receptors assembled from α7 and β2 subunits (α... See on Source

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23/05/2024

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Cocaine Modulates CPY3A4 in Primary Human Macrophages in a Donor-Specific Fashion [ASPET 2024 Annual Meeting Abstract - Neuropharmacology]

Abstract ID 96967 Poster Board 126 CYP3A4 metabolizes 60% of therapeutic drugs, including antiretroviral therapies (ART). CYP3A4 also contributes to cocaine metabolism. People living with HIV that also consume illicit substances have poor virologic contr... See on Source

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23/05/2024

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Pharmacological potentiation of M4 muscarinic acetylcholine receptors suppresses excessive grooming in SAPAP3 knockout mice [ASPET 2024 Annual Meeting Abstract - Neuropharmacology]

Abstract ID 98022 Poster Board 127 Repetitive behaviors are observed in numerous psychiatric and neurodevelopmental disorders, including obsessive-compulsive disorder (OCD) and autism spectrum disorder. The striatum is a brain region that has been demons... See on Source

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23/05/2024

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Role of {beta}-arrestin-2 in the development of opioid withdrawal in the mouse colon [ASPET 2024 Annual Meeting Abstract - Neuropharmacology]

Abstract ID 98219 Poster Board 128 Opioid use disorder (OUD) is a chronic relapsing condition that occurs as a result of repeated use due to the development of tolerance and dependence. The major driver for relapse is the presentation of opioid withdrawa... See on Source

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23/05/2024

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Involvement of Nrf2 and NF-kB Pathways in the Antioxidant and Anti-Inflammatory Effects of Metformin in LPS Activated BV-2 Microglial Cells [ASPET 2024 Annual Meeting Abstract - Neuropharmacology]

Abstract ID 98699 Poster Board 129 Chronic neuroinflammation is associated with several neurodegenerative diseases, such as Alzheimer’s disease. Microglia are the brain’s primary immune cells, and when excessively activated, they cause neuron... See on Source

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23/05/2024

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Defining the Role of D1 and D2 Medium Spiny Neurons in the Nucleus Accumbens in Alcohol Self-Administration [ASPET 2024 Annual Meeting Abstract - Neuropharmacology]

Abstract ID 99086 Poster Board 130 The nucleus accumbens (NAc) is a key site of alcohol-induced dysregulation; however, contextualizing what these changes mean for behavioral control requires a deep understanding of the information encoded within the cel... See on Source

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23/05/2024

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Understanding the Role of Autism Associated Kinase BRSK2 in Neurodevelopment and Disease [ASPET 2024 Annual Meeting Abstract - Neuropharmacology]

Abstract ID 99559 Poster Board 131 Neuronal development is mediated by intricate kinase signaling networks that orchestrate different stages from the begining of neurogenesis to maturation of the synaptic network. Aberrant kinase signaling leads to neuro... See on Source

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23/05/2024

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Enhancement of Opioid Analgesia by Positive Allosteric Modulation of the {mu}-Opioid Receptor in a Rat Model of Chronic Neuropathic Pain [ASPET 2024 Annual Meeting Abstract - Neuropharmacology]

Abstract ID 99807 Poster Board 132 Chronic pain severely impacts the lives of Americans, affecting more that 40% of the U.S. population. Of this group, certain pain conditions like neuropathic pain are inadequately treated by current pharmacotherapies. O... See on Source

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23/05/2024

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Targeting Alpha-2 Adrenergic Receptors for Restoration of Age-Associated Decline in Norepinephrine Release, Long-Term Potentiation and Cognitive Performance [ASPET 2024 Annual Meeting Abstract - Neuropharmacology]

Abstract ID 100341 Poster Board 133 Maintaining optimal levels of catecholamine neurotransmission in the brain is important for regulating arousal/attention, mental focusing, cognition, and affect. Previously, we demonstrated that age-related decreases i... See on Source

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23/05/2024

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Effects of Melatonin on Chemotherapy-Induced Cognitive Impairment and Dendritic Spine Abnormalities in rats [ASPET 2024 Annual Meeting Abstract - Neuropharmacology]

Abstract ID 101024 Poster Board 134 Chemotherapy-induced cognitive impairment, commonly referred to as ‘chemobrain,’ is a prevalent issue affecting a significant proportion of cancer patients, lacking established pharmacological remedies. Thi... See on Source

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23/05/2024

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The Effect of Senolytic Therapy in a Mouse Model of Post-Traumatic Epilepsy [ASPET 2024 Annual Meeting Abstract - Neuropharmacology]

Abstract ID 101688 Poster Board 135 While there are dozens of anti-seizure medications available for patients with epilepsy, up to one third of patients experience seizures refractory to treatment. Identifying treatments that prevent epileptogenesis is a... See on Source

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23/05/2024

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c-Fos Expression in the Hindbrain Following Central Administration of Nociceptin in Heart Failure Rats [ASPET 2024 Annual Meeting Abstract - Neuropharmacology]

Abstract ID 102479 Poster Board 136 Central activation of ORL-1 receptors by nociceptin/opioid like peptide (N/OFQ), in conscious rats, produces marked changes to cardiovascular and renal function in both healthy and heart failure rats. N/OFQ produces it... See on Source

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23/05/2024

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